Osteoporosis is defined as a condition of thinning of bone and bone tissues as a result of lossing of bone density over a long period of time.
Types of food to prevent and treat Osteoporosis
1. Green tea
In the study to investigate whether black tea polyphenol, theaflavin-3,3'-digallate (TFDG) and green tea, epigallocatechin-3-gallate (EGCG)affect MMP activity and osteoclast formation and differentiation in vitro, showed that TFDG and EGCG inhibited the formation and differentiation of
osteoclasts via inhibition of MMPs. TFDG may suppress actin ring
formation more effectively than EGCG. Thus, TFDG and EGCG may be
suitable agents or lead compounds for the treatment of bone resorption
diseases(1).
2. Soy
In the study to clarify the effect of ingesting soy isoflavone extracts (not soy protein or foods containing isoflavones) on bone mineral density (BMD) in menopausal women, found that the varying effects of isoflavones on spine BMD across trials might be
associated with study characteristics of intervention duration (6 vs. 12
months), region of participant (Asian vs. Western), and basal BMD
(normal bone mass vs. osteopenia or osteoporosis). No significant effects on femoral neck, hip total, and trochanter BMD were found. Soy isoflavone extract supplements increased lumbar spine BMD in menopausal women(2).
3. Orange juice
In the study to evaluate the possible variations in antioxidant enzymes, lipid
peroxidation and erythrocyte deformability in experimentally induced
osteoporosis in female rats and to assess the effects of vitamin C
supplementation on those variations, indicated that BMD was significantly lower in the group O than in the group C (p =
0.015), whereas it was significantly higher in the group OVC than in the
group O (p = 0.003). MDA activity was significantly higher in the group
O than in the group C (p = 0.032), whereas it was significantly lower
in the group OVC than in the group O (p = 0.025). SOD activity was
significantly higher in the group O than in the group C (p = 0.032).
Erythrocyte deformability was significantly higher in the group O than
in the group C and OVC (p = 0.008, p = 0.021, respectively)(3).
4. Milk thistle seeds
In the study to investigate that silibinin had bone-forming and osteoprotective
effects in in vitro cell systems of murine osteoblastic MC3T3-E1 cells
and RAW 264.7 murine macrophages, found that that silibinin retarded tartrate-resistant acid phosphatase and
cathepsin K induction and matrix metalloproteinase-9 activity elevated
by RANKL through disturbing TRAF6-c-Src signaling pathways. These
results demonstrate that silibinin was a potential therapeutic agent
promoting bone-forming osteoblastogenesis and encumbering osteoclastic
bone resorption(4).
5. Skin and seed of grape
In the study to investigate the molecular mechanism of how resveratrol can modulate
the lineage commitment of human mesenchymal stem cells to osteogenesis
other than adipogenesis, showed that
resveratrol promoted spontaneous osteogenesis but prevented adipogenesis
in human embryonic stem cell-derived mesenchymal progenitors.
Resveratrol upregulated the expression of osteo-lineage genes RUNX2 and
osteocalcin while suppressing adipo-lineage genes PPARĪ³2 and LEPTIN in
adipogenic medium. Furthermore, the osteogenic effect of
resveratrol was mediated mainly through SIRT1/FOXO3A with a smaller
contribution from the estrogenic pathway(5).
6. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22186621
(2) http://www.ncbi.nlm.nih.gov/pubmed/20199985
(3) http://www.ncbi.nlm.nih.gov/pubmed/22180984
(4) http://www.ncbi.nlm.nih.gov/pubmed/21898547
(5) http://www.ncbi.nlm.nih.gov/pubmed/21713995
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