Thyroid disorders are defined as a condition of anbnomal of thyroid function in production of thyroid hormones (Hyperthyroidsm, if over produced and hypothyroidism if under produced).
Types of food to prevent and treat thyroid disorders
1. Skin and seed of grape
In the study of resveratrol, the main ingredient found in skin and seed of grape and its impact on aging and thyroid function, showed that resveratrol is believed to regulate several biological processes, mainly
metabolism and aging, by modulating the mammalian silent information
regulator 1 (SIRT1) of the sirtuin family. Resveratrol may arrest, among
various tumors, cell growth in both papillary and follicular thyroid
cancer by activation of the mitogen-activated protein kinase (MAPK)
signal transduction pathway as well as increase of p53 and its
phosphorylation. Finally, resveratrol also influences thyroid
function by enhancing iodide trapping and, by increasing TSH secretion
via activation of sirtuins and the phosphatidylinositol- 4-phosphate 5
kinase γ (PIP5Kγ) pathway, positively affects metabolism(1)
2. Green tea
In the comparison of the efficacy of polyphenolic flavonoids found in black and green tea in thyroid function, showed that green tea extract at 2.5 g% and 5.0 g% doses and black tea extract only at 5.0 g% dose have the potential to alter the thyroid gland physiology and architecture, that is, enlargement of thyroid gland as well as hypertrophy and/or hyperplasia of the thyroid follicles and inhibition of the activity of thyroid
peroxidase and 5(')-deiodinase I with elevated thyroidal Na+, K+-ATPase
activity along with significant decrease in serum T3 and T4, and a
parallel increase in serum thyroid stimulating hormone (TSH)(2)
3. Soy and seaweed
In the study to evaluate the relevant literature and provide the clinician guidance for advising their patients about the effects of soy on thyroid function, showed that soy foods, by inhibiting absorption, may increase the dose of thyroid hormone required by hypothyroid patients. However, hypothyroid adults need not avoid soy foods. In addition, there remains a theoretical concern based on in vitro and animal data that in individuals with compromised thyroid function and/or whose iodine intake is marginal soy foods may increase risk of developing clinical hypothyroidism(3). Others suggested that Seaweed ingestion increased I/C concentrations (P < .0001) and serum
TSH (P < .0001) (1.69 +/- 0.22 vs. 2.19 +/- 0.22 microU/mL, mean +/-
SE). Soy supplementation did not affect thyroid
end points. Seven weeks of 5 g/day seaweed supplementation was
associated with a small but statistically significant increase in TSH. Soy protein isolate supplementation was not associated with changes in serum thyroid hormone concentrations(4).
4. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21946130
(2) http://www.ncbi.nlm.nih.gov/pubmed/20801949
(3) http://www.ncbi.nlm.nih.gov/pubmed/16571087
(4) http://www.ncbi.nlm.nih.gov/pubmed/17472472
Wednesday, July 18, 2012
(Phytochemicals in) Foods to Prevent and Treat diseases -Pertussis
Pertussis (whooping cough) is a disease of uncontrollable coughing as a result of infection caused by bacteria Bordetella pertussis
Types of food to prevent and treat Pertussis
1. Green tea and black tea
In the study to evaluate the efficacy of anti bactericidal activity of tea and catechins against Bordetella pertussis, indicated that pu-erh tea killed the bacteria in a moderate way. (-) Epigallocatechin gallate (EGCg) and theaflavin digallate (TF3) showed also marked bactericidal activity. Green tea and black tea also effectively blocked the adhesion of B. pertussis to HeLa and CHO cells, whereas ECGg and TF3 could not. EGCg and TF3 markedly inactivated leuco-lymphocytosis promoting activity of pertussis toxin. Black tea showed slight but significant inactivation of the activity, whereas green tea showed no inactivation(1).
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed?term=green%20tea%20and%20pertussis
Types of food to prevent and treat Pertussis
1. Green tea and black tea
In the study to evaluate the efficacy of anti bactericidal activity of tea and catechins against Bordetella pertussis, indicated that pu-erh tea killed the bacteria in a moderate way. (-) Epigallocatechin gallate (EGCg) and theaflavin digallate (TF3) showed also marked bactericidal activity. Green tea and black tea also effectively blocked the adhesion of B. pertussis to HeLa and CHO cells, whereas ECGg and TF3 could not. EGCg and TF3 markedly inactivated leuco-lymphocytosis promoting activity of pertussis toxin. Black tea showed slight but significant inactivation of the activity, whereas green tea showed no inactivation(1).
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed?term=green%20tea%20and%20pertussis
(Phytochemicals in) Foods to Prevent and Treat diseases - Premenstrual syndrome (PMS)
Premenstrual syndrome effects over 70% to 90% of women before menopause
in the US and less for women in Southeast Asia because of their
difference in living style and social structure. The occurrence of
premenstrual syndrome (PMS) have more than doubled over the past 50
years due to the acceptance of it as a medical condition that is caused
by unhealthy diet with high in saturated food. Premenstrual syndrome
is defined as faulty function of the ovaries related to the women's
menstrual cycle, it effects a women's physical and emotional state, and
sometimes interferes with daily activities as a result of hormone
fluctuation. The syndrome occurs one to two weeks before menstruation
and then declines when the period starts.
Types of food to prevent and treat Premenstrual syndrome (PMS)
1. Wheat Germ
In the study to examine the efficacy of alpha-tocopherol supplementation in reducing specific symptoms of the premenstrual syndrome (PMS), indicated that standardized PMS questionnaires were administered in the luteal phase of the menstrual cycle to all subjects, before and after daily treatment with 400 IU d,alpha-tocopherol or placebo for three cycles. Of the 46 subjects enrolled, 41 completed the clinical trial. A significant improvement in certain affective and physical symptoms was noted in subjects treated with d,alpha-tocopherol(1).
2. Soy
In the study to identify the potential relationship between soy isoflavones and premenstrual syndrome, showed that after two cycles of ISP containing IF intervention, total symptoms (F(2,36) 8.20, P=0.000) and physical symptoms (F(2,36) 8.18, P=0.000) were significantly reduced compared with baseline after both active and placebo treatments, although differences between active and placebo treatment were non-significant. Specific premenstrual symptoms, headache (F(2,32) 4.10, P=0.026) and breast tenderness (F(2,32) 4.59, P=0.018), were reduced from baseline after soy IF, but not milk protein placebo. Cramps (F(2,32) 4.15, P=0.025) and swelling (F(2,32) 4.64, P=0.017) were significantly lower after active treatment compared with placebo. Concentrations of genistein and daidzein were increased following soy IF consumption, but equol production did not enhance symptom reduction(2).
3. Neptune Krill oil and fish oil
In the study to evaluate the effectiveness of Neptune Krill Oil (NKO) for the management of premenstrual syndrome and dysmenorrhea, showed that Neptune Krill Oil can significantly reduce dysmenorrhea and the emotional symptoms of premenstrual syndrome and is shown to be significantly more effective for the complete management of premenstrual symptoms compared to omega-3 fish oil(3).
4. Etc.
Resources
(1) http://www.ncbi.nlm.nih.gov/pubmed/3302248
(2) http://www.ncbi.nlm.nih.gov/pubmed/15975174
(3) http://www.ncbi.nlm.nih.gov/pubmed/12777162
Types of food to prevent and treat Premenstrual syndrome (PMS)
1. Wheat Germ
In the study to examine the efficacy of alpha-tocopherol supplementation in reducing specific symptoms of the premenstrual syndrome (PMS), indicated that standardized PMS questionnaires were administered in the luteal phase of the menstrual cycle to all subjects, before and after daily treatment with 400 IU d,alpha-tocopherol or placebo for three cycles. Of the 46 subjects enrolled, 41 completed the clinical trial. A significant improvement in certain affective and physical symptoms was noted in subjects treated with d,alpha-tocopherol(1).
2. Soy
In the study to identify the potential relationship between soy isoflavones and premenstrual syndrome, showed that after two cycles of ISP containing IF intervention, total symptoms (F(2,36) 8.20, P=0.000) and physical symptoms (F(2,36) 8.18, P=0.000) were significantly reduced compared with baseline after both active and placebo treatments, although differences between active and placebo treatment were non-significant. Specific premenstrual symptoms, headache (F(2,32) 4.10, P=0.026) and breast tenderness (F(2,32) 4.59, P=0.018), were reduced from baseline after soy IF, but not milk protein placebo. Cramps (F(2,32) 4.15, P=0.025) and swelling (F(2,32) 4.64, P=0.017) were significantly lower after active treatment compared with placebo. Concentrations of genistein and daidzein were increased following soy IF consumption, but equol production did not enhance symptom reduction(2).
3. Neptune Krill oil and fish oil
In the study to evaluate the effectiveness of Neptune Krill Oil (NKO) for the management of premenstrual syndrome and dysmenorrhea, showed that Neptune Krill Oil can significantly reduce dysmenorrhea and the emotional symptoms of premenstrual syndrome and is shown to be significantly more effective for the complete management of premenstrual symptoms compared to omega-3 fish oil(3).
4. Etc.
Resources
(1) http://www.ncbi.nlm.nih.gov/pubmed/3302248
(2) http://www.ncbi.nlm.nih.gov/pubmed/15975174
(3) http://www.ncbi.nlm.nih.gov/pubmed/12777162
Tuesday, July 17, 2012
(Phytochemicals in) Foods to Prevent and Treat diseases - Pelvic inflammatory disease
Pelvic inflammation disease (PID) is defined as condition caused by inflammation or infection of the female uterus, fallopian tubes, and/or ovaries as a result of scars
and adhesion in the pelvic which in turn may prevent the implantation
of egg during natural pregnancy process. It affects over 1 million
women in U.S. every month and most of them are in their teen and
twenties and over 100,000 women become infertile in the US alone each year.
Types of food to prevent and treat Pelvic inflammatory disease
1. Turmeric
According to the study of evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation by Satoskar RR, Shah SJ, Shenoy SG., poated in US National Library of Medicine National Institutes of Health, researchers wrote that In this model of postoperative inflammation, the anti-inflammatory activity of curcumin (diferuloyl methane) was investigated in comparison with phenylbutazone and placebo. Phenylbutazone and curcumin produced a better anti-inflammatory response than placebo(1).
2. Soy
In the study of Changes in the anti-inflammatory activity of soy isoflavonoidgenistein versus genistein incorporated in two types of cyclodextrin derivatives, found that genistein is an active anti-inflammatory phytocompound andits complexation with hydrophilic beta-cyclodextrin derivatives leads to a stronger antiinflammatoryactivity(2).
3. Skin and seed of grape
Anti-inflammatory effects of resveratrol and its potential use in therapy of immune-mediated diseases review provides an up-to-date discussion on recent advances regarding anti-inflammatory effects of resveratrol, mechanisms of action, and its potential for therapeutic use(3).
4. Garlic
In the study of Sulfur compounds isolated from garlic exert anti-inflammatory properties, suggested that thiacremonone exerted its anti-inflammatory and anti-arthritic properties through the inhibition of NF-kappaB activation via interaction with the sulfhydryl group of NF-kappaB molecules, and thus could be a useful agent for the treatment of inflammatory and arthritic diseases(4).
5. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/3546166
(2) http://www.ncbi.nlm.nih.gov/pubmed/22716299
(3) http://www.ncbi.nlm.nih.gov/pubmed/22587021
(4) http://www.ncbi.nlm.nih.gov/pubmed/19788760
Types of food to prevent and treat Pelvic inflammatory disease
1. Turmeric
According to the study of evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation by Satoskar RR, Shah SJ, Shenoy SG., poated in US National Library of Medicine National Institutes of Health, researchers wrote that In this model of postoperative inflammation, the anti-inflammatory activity of curcumin (diferuloyl methane) was investigated in comparison with phenylbutazone and placebo. Phenylbutazone and curcumin produced a better anti-inflammatory response than placebo(1).
2. Soy
In the study of Changes in the anti-inflammatory activity of soy isoflavonoidgenistein versus genistein incorporated in two types of cyclodextrin derivatives, found that genistein is an active anti-inflammatory phytocompound andits complexation with hydrophilic beta-cyclodextrin derivatives leads to a stronger antiinflammatoryactivity(2).
3. Skin and seed of grape
Anti-inflammatory effects of resveratrol and its potential use in therapy of immune-mediated diseases review provides an up-to-date discussion on recent advances regarding anti-inflammatory effects of resveratrol, mechanisms of action, and its potential for therapeutic use(3).
4. Garlic
In the study of Sulfur compounds isolated from garlic exert anti-inflammatory properties, suggested that thiacremonone exerted its anti-inflammatory and anti-arthritic properties through the inhibition of NF-kappaB activation via interaction with the sulfhydryl group of NF-kappaB molecules, and thus could be a useful agent for the treatment of inflammatory and arthritic diseases(4).
5. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/3546166
(2) http://www.ncbi.nlm.nih.gov/pubmed/22716299
(3) http://www.ncbi.nlm.nih.gov/pubmed/22587021
(4) http://www.ncbi.nlm.nih.gov/pubmed/19788760
(Phytochemicals in) Foods to Prevent and Treat diseases - Parkinson's disease
Parkinson's disease is defined as a health condition associated to the
depletion of dopamine in the corpus striatum as a result of neuron loss
in the substantianigra. The disease most often occurs in the middle age
and beyond.
Types of food to prevent and treat Parkinson's disease
1. Fish
In the review the use of antioxidants and other supplements for the prevention and treatment of Parkinson's disease (PD), showed that antioxidants and supplements appear to have a limited role in the prevention or treatment of PD. Of those reviewed here, CoQ10 appears to provide some minor treatment benefits(1).
2. Green tea
In the study of Differential effects of black versus green tea on risk of Parkinson's disease in the Singapore Chinese Health Study, found that total caffeine intake was inversely related to Parkinson's disease risk (p for trend = 0.002); the relative risk for the highest versus lowest quartile was 0.55 (95% confidence interval: 0.35, 0.88). Black tea, a caffeine-containing beverage, showed an inverse association with Parkinson's disease risk that was not confounded by total caffeine intake or tobacco smoking (p for trend = 0.0006; adjusted relative risk for the highest vs. lowest tertile of intake = 0.29, 95% confidence interval: 0.13, 0.67). Green tea drinking was unrelated to Parkinson's disease risk. Diet had no strong influence on risk. Ingredients of black tea other than caffeine appear to be responsible for the beverage's inverse association with Parkinson's disease(2).
3. Skin and seed of grapes
In the study to investigate the neuroprotective effects of resveratrol on 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease in rats. 6-OHDA-induced Parkinson's disease rat model involves chronic inflammation, mitochondrial dysfunction, and oxidative stress, and the loss of the dopaminergic neurons in the substantia nigra is the predominant lesion, found that resveratrol treatment also significantly decreased the levels of COX-2 and TNF-alpha mRNA in the substantia nigra as detected by real-time RT-PCR. COX-2 protein expression in the substantia nigra was also decreased as evidenced by Western blotting. These results demonstrate that resveratrol exerts a neuroprotective effect on 6-OHDA-induced Parkinson's disease rat model, and this protection is related to the reduced inflammatory reaction(3)
4. Soy
In the study of the protective effect of the bioflavonoid quercetin on behaviors, antioxidases, and neurotransmitters in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-(MPTP-) induced Parkinson's disease (PD, show that quercetin treatment markedly improves the motor balance and coordination of MPTP-treated mice. Significant increases were observed in the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and Na(+), K(+)-ATPase, AchE, the content of dopamine (DA) in the quercetin plus MPTP groups compared to those in the MPTP group. Significant reduction the 4-hydroxy-2-nonenal (4-HNE) immunoreactivity in striatum of brains was observed in the quercetin plus MPTP groups in comparison to the MPTP group. Taken together, we propose that quercetin has shown antiparkinsonian properties in our studies. More work is needed to explore detailed mechanisms of action(4)
5. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/16622156
(2) http://www.ncbi.nlm.nih.gov/pubmed/18156141
(3) http://www.ncbi.nlm.nih.gov/pubmed/18940189
(4) http://www.ncbi.nlm.nih.gov/pubmed/22454690
Types of food to prevent and treat Parkinson's disease
1. Fish
In the review the use of antioxidants and other supplements for the prevention and treatment of Parkinson's disease (PD), showed that antioxidants and supplements appear to have a limited role in the prevention or treatment of PD. Of those reviewed here, CoQ10 appears to provide some minor treatment benefits(1).
2. Green tea
In the study of Differential effects of black versus green tea on risk of Parkinson's disease in the Singapore Chinese Health Study, found that total caffeine intake was inversely related to Parkinson's disease risk (p for trend = 0.002); the relative risk for the highest versus lowest quartile was 0.55 (95% confidence interval: 0.35, 0.88). Black tea, a caffeine-containing beverage, showed an inverse association with Parkinson's disease risk that was not confounded by total caffeine intake or tobacco smoking (p for trend = 0.0006; adjusted relative risk for the highest vs. lowest tertile of intake = 0.29, 95% confidence interval: 0.13, 0.67). Green tea drinking was unrelated to Parkinson's disease risk. Diet had no strong influence on risk. Ingredients of black tea other than caffeine appear to be responsible for the beverage's inverse association with Parkinson's disease(2).
3. Skin and seed of grapes
In the study to investigate the neuroprotective effects of resveratrol on 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease in rats. 6-OHDA-induced Parkinson's disease rat model involves chronic inflammation, mitochondrial dysfunction, and oxidative stress, and the loss of the dopaminergic neurons in the substantia nigra is the predominant lesion, found that resveratrol treatment also significantly decreased the levels of COX-2 and TNF-alpha mRNA in the substantia nigra as detected by real-time RT-PCR. COX-2 protein expression in the substantia nigra was also decreased as evidenced by Western blotting. These results demonstrate that resveratrol exerts a neuroprotective effect on 6-OHDA-induced Parkinson's disease rat model, and this protection is related to the reduced inflammatory reaction(3)
4. Soy
In the study of the protective effect of the bioflavonoid quercetin on behaviors, antioxidases, and neurotransmitters in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-(MPTP-) induced Parkinson's disease (PD, show that quercetin treatment markedly improves the motor balance and coordination of MPTP-treated mice. Significant increases were observed in the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and Na(+), K(+)-ATPase, AchE, the content of dopamine (DA) in the quercetin plus MPTP groups compared to those in the MPTP group. Significant reduction the 4-hydroxy-2-nonenal (4-HNE) immunoreactivity in striatum of brains was observed in the quercetin plus MPTP groups in comparison to the MPTP group. Taken together, we propose that quercetin has shown antiparkinsonian properties in our studies. More work is needed to explore detailed mechanisms of action(4)
5. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/16622156
(2) http://www.ncbi.nlm.nih.gov/pubmed/18156141
(3) http://www.ncbi.nlm.nih.gov/pubmed/18940189
(4) http://www.ncbi.nlm.nih.gov/pubmed/22454690
(Phytochemicals in) Foods to Prevent and Treat diseases - Otitis media (middle ear infection)
Otitis media is defined as an acute or chronic condition of middle ear infection, effecting mostly infants and young children.
Types of food to prevent and treat Otitis media
1. Orange peel
In the study to investigate the Effect of orange peel essential oil on oxidative stress in AOM animals
showed that orange peel essential oil treatment could decrease serum and cochlea malondialdehyde (MDA), immunoglobulins A (IgA), immunoglobulins G (IgG), immunoglobulins M (IgM) levels and increase antioxidant enzymes activitie and concluded that orange peel essential oil treatment could decrease oxidative injury in acute otitis media rats(1).
2. Carrot and tomato
In the study to investigate therapeutic role of tvitamin A on healing of middle ear mucosa in experimental acute otitis media (AOM), showed that Pretreatment with vitamin A increases antioxidant enzyme activities and reduces formation of NO and MDA. Vitamin A may be considered as an additional medicament for the medical treatment of AOM(2).
3. Garlic and onions
In the study to evaluate the effects of GSH treatment on chronic otitis media with effusion (OME), found that three months after therapy improvement had occurred in 66.6% of patients in the GSH-treated group and in 8% of the control subjects (P <.01)(3).
4. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22342737
(2) http://www.ncbi.nlm.nih.gov/pubmed/17303254
(3) http://www.ncbi.nlm.nih.gov/pubmed/11568588
Types of food to prevent and treat Otitis media
1. Orange peel
In the study to investigate the Effect of orange peel essential oil on oxidative stress in AOM animals
showed that orange peel essential oil treatment could decrease serum and cochlea malondialdehyde (MDA), immunoglobulins A (IgA), immunoglobulins G (IgG), immunoglobulins M (IgM) levels and increase antioxidant enzymes activitie and concluded that orange peel essential oil treatment could decrease oxidative injury in acute otitis media rats(1).
2. Carrot and tomato
In the study to investigate therapeutic role of tvitamin A on healing of middle ear mucosa in experimental acute otitis media (AOM), showed that Pretreatment with vitamin A increases antioxidant enzyme activities and reduces formation of NO and MDA. Vitamin A may be considered as an additional medicament for the medical treatment of AOM(2).
3. Garlic and onions
In the study to evaluate the effects of GSH treatment on chronic otitis media with effusion (OME), found that three months after therapy improvement had occurred in 66.6% of patients in the GSH-treated group and in 8% of the control subjects (P <.01)(3).
4. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22342737
(2) http://www.ncbi.nlm.nih.gov/pubmed/17303254
(3) http://www.ncbi.nlm.nih.gov/pubmed/11568588
(Phytochemicals in) Foods to Prevent and Treat diseases - Osteoporosis
Osteoporosis is defined as a condition of thinning of bone and bone tissues as a result of lossing of bone density over a long period of time.
Types of food to prevent and treat Osteoporosis
1. Green tea
In the study to investigate whether black tea polyphenol, theaflavin-3,3'-digallate (TFDG) and green tea, epigallocatechin-3-gallate (EGCG)affect MMP activity and osteoclast formation and differentiation in vitro, showed that TFDG and EGCG inhibited the formation and differentiation of osteoclasts via inhibition of MMPs. TFDG may suppress actin ring formation more effectively than EGCG. Thus, TFDG and EGCG may be suitable agents or lead compounds for the treatment of bone resorption diseases(1).
2. Soy
In the study to clarify the effect of ingesting soy isoflavone extracts (not soy protein or foods containing isoflavones) on bone mineral density (BMD) in menopausal women, found that the varying effects of isoflavones on spine BMD across trials might be associated with study characteristics of intervention duration (6 vs. 12 months), region of participant (Asian vs. Western), and basal BMD (normal bone mass vs. osteopenia or osteoporosis). No significant effects on femoral neck, hip total, and trochanter BMD were found. Soy isoflavone extract supplements increased lumbar spine BMD in menopausal women(2).
3. Orange juice
In the study to evaluate the possible variations in antioxidant enzymes, lipid peroxidation and erythrocyte deformability in experimentally induced osteoporosis in female rats and to assess the effects of vitamin C supplementation on those variations, indicated that BMD was significantly lower in the group O than in the group C (p = 0.015), whereas it was significantly higher in the group OVC than in the group O (p = 0.003). MDA activity was significantly higher in the group O than in the group C (p = 0.032), whereas it was significantly lower in the group OVC than in the group O (p = 0.025). SOD activity was significantly higher in the group O than in the group C (p = 0.032). Erythrocyte deformability was significantly higher in the group O than in the group C and OVC (p = 0.008, p = 0.021, respectively)(3).
4. Milk thistle seeds
In the study to investigate that silibinin had bone-forming and osteoprotective effects in in vitro cell systems of murine osteoblastic MC3T3-E1 cells and RAW 264.7 murine macrophages, found that that silibinin retarded tartrate-resistant acid phosphatase and cathepsin K induction and matrix metalloproteinase-9 activity elevated by RANKL through disturbing TRAF6-c-Src signaling pathways. These results demonstrate that silibinin was a potential therapeutic agent promoting bone-forming osteoblastogenesis and encumbering osteoclastic bone resorption(4).
5. Skin and seed of grape
In the study to investigate the molecular mechanism of how resveratrol can modulate the lineage commitment of human mesenchymal stem cells to osteogenesis other than adipogenesis, showed that
resveratrol promoted spontaneous osteogenesis but prevented adipogenesis in human embryonic stem cell-derived mesenchymal progenitors. Resveratrol upregulated the expression of osteo-lineage genes RUNX2 and osteocalcin while suppressing adipo-lineage genes PPARγ2 and LEPTIN in adipogenic medium. Furthermore, the osteogenic effect of resveratrol was mediated mainly through SIRT1/FOXO3A with a smaller contribution from the estrogenic pathway(5).
6. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22186621
(2) http://www.ncbi.nlm.nih.gov/pubmed/20199985
(3) http://www.ncbi.nlm.nih.gov/pubmed/22180984
(4) http://www.ncbi.nlm.nih.gov/pubmed/21898547
(5) http://www.ncbi.nlm.nih.gov/pubmed/21713995
Types of food to prevent and treat Osteoporosis
1. Green tea
In the study to investigate whether black tea polyphenol, theaflavin-3,3'-digallate (TFDG) and green tea, epigallocatechin-3-gallate (EGCG)affect MMP activity and osteoclast formation and differentiation in vitro, showed that TFDG and EGCG inhibited the formation and differentiation of osteoclasts via inhibition of MMPs. TFDG may suppress actin ring formation more effectively than EGCG. Thus, TFDG and EGCG may be suitable agents or lead compounds for the treatment of bone resorption diseases(1).
2. Soy
In the study to clarify the effect of ingesting soy isoflavone extracts (not soy protein or foods containing isoflavones) on bone mineral density (BMD) in menopausal women, found that the varying effects of isoflavones on spine BMD across trials might be associated with study characteristics of intervention duration (6 vs. 12 months), region of participant (Asian vs. Western), and basal BMD (normal bone mass vs. osteopenia or osteoporosis). No significant effects on femoral neck, hip total, and trochanter BMD were found. Soy isoflavone extract supplements increased lumbar spine BMD in menopausal women(2).
3. Orange juice
In the study to evaluate the possible variations in antioxidant enzymes, lipid peroxidation and erythrocyte deformability in experimentally induced osteoporosis in female rats and to assess the effects of vitamin C supplementation on those variations, indicated that BMD was significantly lower in the group O than in the group C (p = 0.015), whereas it was significantly higher in the group OVC than in the group O (p = 0.003). MDA activity was significantly higher in the group O than in the group C (p = 0.032), whereas it was significantly lower in the group OVC than in the group O (p = 0.025). SOD activity was significantly higher in the group O than in the group C (p = 0.032). Erythrocyte deformability was significantly higher in the group O than in the group C and OVC (p = 0.008, p = 0.021, respectively)(3).
4. Milk thistle seeds
In the study to investigate that silibinin had bone-forming and osteoprotective effects in in vitro cell systems of murine osteoblastic MC3T3-E1 cells and RAW 264.7 murine macrophages, found that that silibinin retarded tartrate-resistant acid phosphatase and cathepsin K induction and matrix metalloproteinase-9 activity elevated by RANKL through disturbing TRAF6-c-Src signaling pathways. These results demonstrate that silibinin was a potential therapeutic agent promoting bone-forming osteoblastogenesis and encumbering osteoclastic bone resorption(4).
5. Skin and seed of grape
In the study to investigate the molecular mechanism of how resveratrol can modulate the lineage commitment of human mesenchymal stem cells to osteogenesis other than adipogenesis, showed that
resveratrol promoted spontaneous osteogenesis but prevented adipogenesis in human embryonic stem cell-derived mesenchymal progenitors. Resveratrol upregulated the expression of osteo-lineage genes RUNX2 and osteocalcin while suppressing adipo-lineage genes PPARγ2 and LEPTIN in adipogenic medium. Furthermore, the osteogenic effect of resveratrol was mediated mainly through SIRT1/FOXO3A with a smaller contribution from the estrogenic pathway(5).
6. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22186621
(2) http://www.ncbi.nlm.nih.gov/pubmed/20199985
(3) http://www.ncbi.nlm.nih.gov/pubmed/22180984
(4) http://www.ncbi.nlm.nih.gov/pubmed/21898547
(5) http://www.ncbi.nlm.nih.gov/pubmed/21713995
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